Yvette Nicole Brown graduated from the University of Akron. She began her career appearing in TV commercials, later transitioning to television projects and films (starting with the video release His Woman, His Wife in 2000).
Brown has since chalked up appearances in numerous television shows such as Curb Your Enthusiasm, Malcolm in the Middle, House and The Office. She held a recurring role in the Nickelodeon series Drake & Josh, as cinema owner Helen Dubuois. She also starred in the films The Island, Tropic Thunder and The Ugly Truth, among others.
Currently Brown is part of the cast of the NBC comedy Community, appearing as single mother Shirley Bennett. She also provides her voice to the pre-school series Pound Puppies.