The daughter of two teachers, Sprague Grayden has been pursuing a career as an actress since the age of 5. She consequently spent the majority of her adolescence appearing in various commercials and stage plays, and even made her cinematic debut in 1989 with a small role opposite Kevin Spacey and Ethan Hawke in the tearjerker Dad.
Sprague was raised with a keen understanding of the importance of education and decided to put her burgeoning career on hold until she finished college — she graduated cum laude from Barnard College at Columbia University.
After college, Sprague threw herself completely into the rigorous auditioning process and quickly landed a role in the schlock horror film Biohazardous (2001), as well as a one-shot appearance on Law & Order: Special Victims Unit.
Her big break came in 2002 with a recurring role on the FOX series John Doe, which also starred Prison Break actor Dominic Purcell. Though the show was cancelled after its first season, Sprague was invited to audition for more prominent parts, which led to appearances on Crossing Jordan, Joan of Arcadia and Six Feet Under.
A starring role on the highly anticipated 2006 CBS show Jericho — opposite Skeet Ulrich and Ashley Scott — made it clear that Sprague Grayden will have a long and fruitful career.